Impact of global trade agreements on agricultural producer prices in Asian countries.

Following global trade agreements, Asian countries have been highly aggressive in implementing free trade. These conditions will impact all sectors, including agriculture. This study aims to examine the impact of the General Agreement on Tariffs and Trade (GATT), World Trade Organization membership (WTO), and the Doha Round implementations on agricultural producer prices in Asian countries (PPI). The study was conducted using secondary data from 1991 to 2020. The data for 28 Asian countries were analyzed using the first difference General Method of Moments (GMM). The results show that implementing the GATT raises the PPI, but implementing the WTO has the reverse impact. PPI is unaffected by the Doha Round. Inflation, exchange rate, value-added, human capital, and land area equipped for irrigation are all positive contributors to PPI. Several recommendations are made to increase PPI in Asian countries: increasing commitment to agricultural fair trade, increasing agricultural value-added, improving educational opportunities for agricultural business players, and prioritizing agricultural infrastructure investment.

A bioinformatic approach to identify pathogenic variants for Stevens-Johnson syndrome.

Stevens-Johnson syndrome (SJS) produces a severe hypersensitivity reaction caused by Herpes simplex virus or mycoplasma infection, vaccination, systemic disease, or other agents. Several studies have investigated the genetic susceptibility involved in SJS. To provide further genetic insights into the pathogenesis of SJS, this study prioritized high-impact, SJS-associated pathogenic variants through integrating bioinformatic and population genetic data. First, we identified SJS-associated single nucleotide polymorphisms from the genome-wide association studies catalog, followed by genome annotation with HaploReg and variant validation with Ensembl. Subsequently, expression quantitative trait locus (eQTL) from GTEx identified human genetic variants with differential gene expression across human tissues. Our results indicate that two variants, namely rs2074494 and rs5010528, which are encoded by the HLA-C (human leukocyte antigen C) gene, were found to be differentially expressed in skin. The allele frequencies for rs2074494 and rs5010528 also appear to significantly differ across continents. We highlight the utility of these population-specific HLA-C genetic variants for genetic association studies, and aid in early prognosis and disease treatment of SJS.

A genomic and bioinformatic-based approach to identify genetic variants for liver cancer across multiple continents.

Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity, and type 2 diabetes. Genomic variants play a crucial role in mediating the associations between these risk factors and liver cancer. However, the specific variants involved in this process remain under-explored. This study utilized a bioinformatics approach to identify genetic variants associated with liver cancer from various continents. Single-nucleotide polymorphisms associated with liver cancer were retrieved from the genome-wide association studies catalog. Prioritization was then performed using functional annotation with HaploReg v4.1 and the Ensembl database. The prevalence and allele frequencies of each variant were evaluated using Pearson correlation coefficients. Two variants, rs2294915 and rs2896019, encoded by the PNPLA3 gene, were found to be highly expressed in the liver tissue, as well as in the skin, cell-cultured fibroblasts, and adipose-subcutaneous tissue, all of which contribute to the risk of liver cancer. We further found that these two SNPs (rs2294915 and rs2896019) were positively correlated with the prevalence rate. Positive associations with the prevalence rate were more frequent in East Asian and African populations. We highlight the utility of this population-specific PNPLA3 genetic variant for genetic association studies and for the early prognosis and treatment of liver cancer. This study highlights the potential of integrating genomic databases with bioinformatic analysis to identify genetic variations involved in the pathogenesis of liver cancer. The genetic variants investigated in this study are likely to predispose to liver cancer and could affect its progression and aggressiveness. We recommend future research prioritizing the validation of these variations in clinical settings.

Coffee Yield Stability as a Factor of Food Security.

Yield fluctuation is a major risk in all agricultural sectors, and it influences Goal 2 (food security) of the UN SDGs. Yield fluctuations are expected due to climate change, risking stable coffee supplies, and compromising coffee-exporting countries' ability to earn revenue to pay for food imports. Technology minimizing yield fluctuations is crucial for food security and for coffee farmers to earn a stable income. Fluctuations are small if yields remain close to the mean yield trends. In this study, the coffee yields of major producers are analyzed, together with zonal temperature data, to see where coffee is grown with stable technology under rising temperatures; thus, we demonstrate the advantages of the Yield Stability Index (YSI) over traditional stability measurements in guiding policy formulation and managerial decisions. The Yield Stability Index (YSI) is applied for 1961-1994 and 1995-2020, for the world's 12 major coffee-producing countries. The YSI indicates that of the 12 countries, only Indonesia, Honduras, and Mexico maintain stable yield levels, while Brazil and Vietnam considerably improve their yield stability, which traditional stability measures cannot grasp. Country-wise differences exist in environmental vulnerability and adaptability, with implications for food security. The novelty is the application of the YSI, and the connection between yield stability, climate change, and food security.